Article
Suppression of multiple anti-apoptotic BCL2 family proteins recapitulates the effects of JAK2 inhibitors in JAK2V617F driven myeloproliferative neoplasms.
Cancer science - 1 Feb 2022
Takei Hisashi, Coelho-Silva Juan Luiz, Tavares Leal Cristina, Queiroz Arantes Rocha Adriana, Mantello Bianco Thiago, Welner Robert S, Mishima Yuta, Kobayashi Ikei S, Mullally Ann, Lima Keli, Machado-Neto João Agostinho, Kobayashi Susumu S, Lobo de Figueiredo-Pontes Lorena
Abstract excerpt
Several lines of research suggest that Bcl-xL-mediated anti-apoptotic effects may contribute to the pathogenesis of myeloproliferative neoplasms driven by JAK2V617F and serve as therapeutic target. Here, we used a knock-in JAK2V617F mouse model and confirmed that Bcl-xL was overexpressed in erythroid progenitors. The myeloproliferative neoplasm (MPN)-induced phenotype in the peripheral blood by conditional...
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