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Article

In vitro analysis reveals necroptotic signaling does not provoke DNA damage or HPRT mutations.

Cell death & disease - 13 Aug 2020

Miles Mark A, Hawkins Christine J

Abstract excerpt

Most anticancer drugs provoke apoptotic signaling by damaging DNA or other means. Genotoxic therapies may enhance a patient's risk of developing "therapy-related cancers" due to the accumulation of oncogenic mutations that may occur in noncancerous cells. Mutations can also form upon apoptotic signaling due to sublethal caspase activity, implying that apoptosis activating drugs may also be oncogenic. Necroptosis...

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Identifiers

PMID: 32826875
DOI: 10.1038/s41419-020-02879-y
PMCID: PMC7442655

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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