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Article

Smac mimetic induces cell death in a large proportion of primary acute myeloid leukemia samples, which correlates with defined molecular markers.

Oncotarget - 2 Aug 2016

Lueck Sonja C, Russ Annika C, Botzenhardt Ursula, Schlenk Richard F, Zobel Kerry, Deshayes Kurt, Vucic Domagoj, Döhner Hartmut, Döhner Konstanze, Fulda Simone, Bullinger Lars

Abstract excerpt

Apoptosis is deregulated in most, if not all, cancers, including hematological malignancies. Smac mimetics that antagonize Inhibitor of Apoptosis (IAP) proteins have so far largely been investigated in acute myeloid leukemia (AML) cell lines; however, little is yet known on the therapeutic potential of Smac mimetics in primary AML samples. In this study, we therefore investigated the antileukemic activity of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, Tumor Necrosis Factor, Type I

Source

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Identifiers

PMID: 27385100
DOI: 10.18632/oncotarget.10390
PMCID: PMC5226527

Genes

NPM1
TNF
XIAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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