Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The SMAC mimetic BV6 induces cell death and sensitizes different cell lines to TNF-α and TRAIL-induced apoptosis

27 Jul 2016

Abstract excerpt

The inhibitors of apoptosis proteins are implicated in promoting cancer cells survival and resistance toward immune surveillance and chemotherapy. Second mitochondria-derived activator of caspases (SMAC) mimetics are novel compounds developed to mimic the inhibitory effect of the endogenous SMAC/DIABLO on these IAPs. Here, we examined the potential effects of the novel SMAC mimetic BV6 on different human cancer...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Cell death mechanisms and regulation
Share to Phagocytosis and Immune Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27465142
DOI: 10.1177/1535370216661779

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The SMAC mimetic BV6 induces cell death and sensitizes different cell lines to TNF-α and TRAIL-induced apoptosisPMID 27465142Read ↗

Molecular Pathways: Targeting Death Receptors and Smac MimeticsSemantic proximity Read ↗

Targeting the inhibitors of apoptosis proteins (IAPs) to combat drug resistance in cancersSemantic proximity Read ↗

Targeting XIAP for Promoting Cancer Cell Death—The Story of ARTS and SMACSemantic proximity Read ↗

Smac mimetic induces cell death in a large proportion of primary acute myeloid leukemia samples, which correlates with defined molecular markers.Semantic proximity Read ↗

X-Linked Inhibitor of Apoptosis Protein â€“ A Critical Death Resistance Regulator and Therapeutic Target for Personalized Cancer TherapySemantic proximity Read ↗

IAP antagonists Birinapant and AT-406 efficiently synergise with either TRAIL, BRAF, or BCL-2 inhibitors to sensitise BRAFV600E colorectal tumour cells to apoptosis.Semantic proximity Read ↗

Caspase‐mediated programmed cell death pathways as potential therapeutic targets in cancerSemantic proximity Read ↗

Cancer therapy in the necroptosis eraSemantic proximity Read ↗

Smac mimetics and TRAIL cooperate to induce MLKL-dependent necroptosis in Burkitt's lymphoma cell linesSemantic proximity Read ↗

Mitochondrial permeabilization engages NF-κB-dependent anti-tumour activity under caspase deficiency.Semantic proximity Read ↗

The Second Mitochondrial Activator of Caspases (SMAC) regulates growth, inflammation and mitochondrial integrity in cancer cellsSemantic proximity Read ↗

Inhibition of IAPs induces programmed cell death and inflammatory signaling in patient-derived metastatic breast cancer organoidsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.