Article
Mesenchymal stem cells elicit macrophages into M2 phenotype via improving transcription factor EB-mediated autophagy to alleviate diabetic nephropathy.
Stem cells (Dayton, Ohio) - 1 May 2020
Yuan Yujia, Li Lan, Zhu Lingling, Liu Fei, Tang Xi, Liao Guangneng, Liu Jingping, Cheng Jingqiu, Chen Younan, Lu Yanrong
Abstract excerpt
Diabetic nephropathy (DN) is a leading cause of end-stage renal disease. Chronic inflammation is recognized as a key causal factor in the development and progression of DN, and the imbalance of M1/M2 macrophages (Mφ) contributes to this process. Mesenchymal stem cells (MSCs) have been reported to prevent renal injuries via immune regulation in diabetic models, but whether these benefits are owing to the...
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