Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effects of a CCR2 antagonist on macrophages and Toll-like receptor 9 expression in a mouse model of diabetic nephropathy.

American journal of physiology. Renal physiology - 1 Dec 2021

Ito Seigo, Nakashima Hiroyuki, Ishikiriyama Takuya, Nakashima Masahiro, Yamagata Akira, Imakiire Toshihiko, Kinoshita Manabu, Seki Shuhji, Kumagai Hiroo, Oshima Naoki

Abstract excerpt

The pathogenesis of diabetic nephropathy (DN) is related to macrophage (Mφ) recruitment to the kidneys, tumor necrosis factor-α (TNF-α) production, and oxidative stress. Toll-like receptor 9 (TLR9) activation is reportedly involved in systemic inflammation, and it exacerbates this condition in metabolic syndrome. Therefore, we hypothesized that TLR9 plays a role in the pathogenesis of DN. Two subsets of kidney...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diabetic Nephropathies
Share to Kidney

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phagocytosis

Share to Pyrrolidines

Share to Reactive Oxygen Species

Share to Receptors, CCR2

Share to Receptors, Leptin

Share to Toll-Like Receptor 9

Source

Identifiers

PMID: 34719947
DOI: 10.1152/ajprenal.00191.2021

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effects of a CCR2 antagonist on macrophages and Toll-like receptor 9 expression in a mouse model of diabetic nephropathy.PMID 34719947Read ↗

Pathogenic and protective role of macrophages in kidney disease.Semantic proximity Read ↗

Vitamin D prevents podocyte injury via regulation of macrophage M1/M2 phenotype in diabetic nephropathy rats.Semantic proximity Read ↗

Podocyte-specific chemokine (C-C motif) receptor 2 overexpression mediates diabetic renal injury in mice.Semantic proximity Read ↗

Renal F4/80+ CD11c+ mononuclear phagocytes display phenotypic and functional characteristics of macrophages in health and in adriamycin nephropathy.Semantic proximity Read ↗

Macrophages in renal disease.Semantic proximity Read ↗

Macrophage Phenotype and Fibrosis in Diabetic Nephropathy.Semantic proximity Read ↗

Macrophage-derived tumor necrosis factor-α mediates diabetic renal injury.Semantic proximity Read ↗

Macrophages polarization in renal inflammation and fibrosis animal models (Review)Semantic proximity Read ↗

Clec7a expression in inflammatory macrophages orchestrates progression of acute kidney injurySemantic proximity Read ↗

Bee Venom Melittin Protects against Cisplatin-Induced Acute Kidney Injury in Mice via the Regulation of M2 Macrophage Activation.Semantic proximity Read ↗

Relationship between Macrophages and Tissue Microenvironments in Diabetic KidneysSemantic proximity Read ↗

Dendritic Cells and Macrophages: Sentinels in the Kidney.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.