Article
Analysis of DNA methylation in endometrial biopsies to predict risk of endometrial cancer.
Gynecologic oncology - 1 Mar 2020
Multinu Francesco, Chen Jun, Madison Joseph D, Torres Michelle, Casarin Jvan, Visscher Daniel, Shridhar Viji, Bakkum-Gamez Jamie, Sherman Mark, Wentzensen Nicolas, Mariani Andrea, Walther-Antonio Marina
Abstract excerpt
OBJECTIVE: To determine whether analysis of methylated DNA in benign endometrial biopsy (EB) specimens is associated with risk of endometrial cancer (EC). METHODS: We identified 23 women with EBs performed at Mayo Clinic diagnosed as normal (n = 14) or hyperplasia (n = 9) and who later developed endometrial cancer after a median interval of 1 year. Cases were matched 1:1 with patients with benign EBs who did not...
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