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Hypermethylated CDO1 and ZNF454 in Cytological Specimens as Screening Biomarkers for Endometrial Cancer

28 Apr 2022

Abstract excerpt

We aimed to estimate the diagnostic value of DNA methylation levels in cytological samples of endometrial cancer (EC) and atypical hyperplasia (AH). Two hypermethylated genes, namely, cysteine dioxygenase type 1 ( CDO1 ) and zinc finger protein 454 ( ZNF454 ), in patients with EC were identified from The Cancer Genome Atlas database. In 103 endometrial histological specimens (the training set), the methylation...

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PMID: 35574348
DOI: 10.3389/fonc.2022.714663

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