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Role of DNA Methylation and Epigenetic Silencing of HAND2 in Endometrial Cancer Development

12 Nov 2013

Abstract excerpt

BACKGROUND: Endometrial cancer incidence is continuing to rise in the wake of the current ageing and obesity epidemics. Much of the risk for endometrial cancer development is influenced by the environment and lifestyle. Accumulating evidence suggests that the epigenome serves as the interface between the genome and the environment and that hypermethylation of stem cell polycomb group target genes is an epigenetic...

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PMID: 24265601
DOI: 10.1371/journal.pmed.1001551

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