Article
Combining copy number, methylation markers, and mutations as a panel for endometrial cancer detection via intravaginal tampon collection.
Gynecologic oncology - 1 Feb 2020
Sangtani Ajleeta, Wang Chen, Weaver Amy, Hoppman Nicole L, Kerr Sarah E, Abyzov Alexej, Shridhar Viji, Staub Julie, Kocher Jean-Pierre A, Voss Jesse S, Podratz Karl C, Wentzensen Nicolas, Kisiel John B, Sherman Mark E, Bakkum-Gamez Jamie N
Abstract excerpt
OBJECTIVE: We aimed to assess whether endometrial cancer (EC) can be detected in shed DNA collected with vaginal tampon by analyzing copy number, methylation markers, and mutations. METHODS: Tampons were collected prior to hysterectomy from 38 EC patients and 28 women with benign indications. Extracted tampon DNA underwent the following: 1) low-coverage whole genome sequencing (LC-WGS) to assess copy number, 2)...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.