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Article

Genetic and epigenetic alterations in precursor lesions of endometrial endometrioid carcinoma.

The Journal of pathology - 1 Jul 2024

Gotoh Osamu, Sugiyama Yuko, Tonooka Akiko, Kosugi Mayuko, Kitaura Sunao, Minegishi Ryu, Sano Masatoshi, Amino Sayuri, Furuya Rie, Tanaka Norio, Kaneyasu Tomoko, Kumegawa Kohei, Abe Akiko, Nomura Hidetaka, Takazawa Yutaka, Kanao Hiroyuki, Maruyama Reo, Noda Tetsuo, Mori Seiichi

Abstract excerpt

The hyperplasia-carcinoma sequence is a stepwise tumourigenic programme towards endometrial cancer in which normal endometrial epithelium becomes neoplastic through non-atypical endometrial hyperplasia (NAEH) and atypical endometrial hyperplasia (AEH), under the influence of unopposed oestrogen. NAEH and AEH are known to exhibit polyclonal and monoclonal cell growth, respectively; yet, aside from focal PTEN...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 38734880
DOI: 10.1002/path.6278

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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