Article
Doping test results dependent on genotype of uridine diphospho-glucuronosyl transferase 2B17, the major enzyme for testosterone glucuronidation.
The Journal of clinical endocrinology and metabolism - 1 Jul 2008
Schulze Jenny Jakobsson, Lundmark Jonas, Garle Mats, Skilving Ilona, Ekström Lena, Rane Anders
Abstract excerpt
CONTEXT: Testosterone abuse is conventionally assessed by the urinary testosterone/epitestosterone (T/E) ratio, levels above 4.0 being considered suspicious. The large variation in testosterone glucuronide (TG) excretion and its strong association with a deletion polymorphism in the uridine diphospho-glucuronosyl transferase (UGT) 2B17 gene challenge the accuracy of the T/E ratio test. OBJECTIVE: Our objective...
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