Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Extensive metabolic consequences of human glycosyltransferase gene knockouts in prostate cancer.

British journal of cancer - 1 Jan 2023

Rouleau Michèle, Nguyen Van Long Flora, Turcotte Véronique, Caron Patrick, Lacombe Louis, Aprikian Armen, Saad Fred, Carmel Michel, Chevalier Simone, Lévesque Eric, Guillemette Chantal

Abstract excerpt

BACKGROUND: Naturally occurring germline gene deletions (KO) represent a unique setting to interrogate gene functions. Complete deletions and differential expression of the human glycosyltransferase UGT2B17 and UGT2B28 genes are linked to prostate cancer (PCa) risk and progression, leukaemia, autoimmune and other diseases. METHODS: The systemic metabolic consequences of UGT deficiencies were examined using...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Knockout Techniques
Share to Glucuronides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glucuronosyltransferase

Share to Phenotype

Share to Prostatic Neoplasms

Share to Steroids

Source

Open in PubMed Open full text

Identifiers

PMID: 36347965
DOI: 10.1038/s41416-022-02040-w
PMCID: PMC9902621

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Extensive metabolic consequences of human glycosyltransferase gene knockouts in prostate cancer.PMID 36347965Read ↗

Sexual dimorphism in metabolomic and phenotypic spectra of UGT deficiency: findings from the Canadian Longitudinal Study on Aging.Semantic proximity Read ↗

Alteration of Lipid Metabolism in Prostate Cancer: Multifaceted Oncologic ImplicationsSemantic proximity Read ↗

Glyoxalases in Urological MalignanciesSemantic proximity Read ↗

The UGT2B28 Sex-steroid Inactivation Pathway Is a Regulator of Steroidogenesis and Modifies the Risk of Prostate Cancer Progression.Semantic proximity Read ↗

Mechanistic Link Between Glyoxalase 1 Expression and Methylglyoxal-Induced Oncogenic Stress in Prostate CancerSemantic proximity Read ↗

UGT pharmacogenomics: implications for cancer risk and cancer therapeutics.Semantic proximity Read ↗

UGT pharmacogenomicsSemantic proximity Read ↗

Emerging roles for UDP-glucuronosyltransferases in drug resistance and cancer progressionSemantic proximity Read ↗

Personalized Medicine for Prostate Cancer: Is Targeting Metabolism a Reality?Semantic proximity Read ↗

Natural Products in Prostate Cancer: Crosstalk among the Gut Microbiome, Androgen Receptor Signaling, and Epigenetic RegulationSemantic proximity Read ↗

Integration of clinical data with a genome‐scale metabolic model of the human adipocyteSemantic proximity Read ↗

Cross-population metabolome-wide Mendelian randomization study of prostate cancer riskSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.