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Article

Proprotein convertases in human atherosclerotic plaques: the overexpression of FURIN and its substrate cytokines BAFF and APRIL.

Atherosclerosis - 1 Dec 2011

Turpeinen Hannu, Raitoharju Emma, Oksanen Anna, Oksala Niku, Levula Mari, Lyytikäinen Leo-Pekka, Järvinen Otso, Creemers John W M, Kähönen Mika, Laaksonen Reijo, Pelto-Huikko Markku, Lehtimäki Terho, Pesu Marko

Abstract excerpt

BACKGROUND: Proprotein convertase subtilisin/kexin (PCSK) enzymes cleave proproteins into mature end products. Previously, MBTPS1 and PCSK9 have been shown to regulate cholesterol metabolism and LDL receptor recycling, whereas FURIN and PCSK5 have been suggested to inactivate lipases and regulate...

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Source

Identifiers

PMID: 21889147
DOI: 10.1016/j.atherosclerosis.2011.08.011

Genes

FURIN
TNFSF13
MBTPS1
PCSK5
PCSK9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21889147-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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