Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inhibition of PCSK6 may play a protective role in the development of rheumatoid arthritis.

The Journal of rheumatology - 1 Feb 2015

Wang Feifei, Wang Lin, Jiang Huiyu, Chang Xiaotian, Pan Jihong

Abstract excerpt

OBJECTIVE: To assess the effect of proprotein convertase subtilisin/kexin type 6 (PCSK6) in the synovial fibroblasts of rheumatoid arthritis (RA). PCSK6 is a proteinase implicated in the proteolytic activity of various precursor proteins and involved in the regulation of protein maturation. METHODS: PCSK6 expression was detected in the synovial tissue of 10 patients with RA, 10 controls with osteoarthritis, and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arthritis, Rheumatoid
Share to Cell Movement
Share to Cytokines

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Osteoarthritis

Share to Proprotein Convertases

Share to Serine Endopeptidases

Share to Spondylitis, Ankylosing

Share to Synovial Membrane

Source

Identifiers

PMID: 25433529
DOI: 10.3899/jrheum.140435

Genes

PCSK6
CCL7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inhibition of PCSK6 may play a protective role in the development of rheumatoid arthritis.PMID 25433529Read ↗

PCSK6 Is a Key Protease in the Control of Smooth Muscle Cell Function in Vascular Remodeling.Semantic proximity Read ↗

Circ_0088194 Promotes the Invasion and Migration of Rheumatoid Arthritis Fibroblast-Like Synoviocytes via the miR-766-3p/MMP2 Axis.Semantic proximity Read ↗

Key regulatory molecules of cartilage destruction in rheumatoid arthritis: an in vitrostudySemantic proximity Read ↗

Association of ADAMTS12 polymorphisms with rheumatoid arthritis.Semantic proximity Read ↗

Mir204 and Mir211 suppress synovial inflammation and proliferation in rheumatoid arthritis by targeting Ssrp1Semantic proximity Read ↗

CYR61 synthesis is Induced by Interleukin-6 and Promotes Migration and Invasion of Fibroblast-like Synoviocytes in Rheumatoid ArthritisSemantic proximity Read ↗

Proprotein Convertase Subtilisin/Kexin Type 9 in the Inflammation-Related Dyslipidemia of Patients with Axial Spondyloarthritis is Related to Disease Activity.Semantic proximity Read ↗

C5orf30 is a negative regulator of tissue damage in rheumatoid arthritis.Semantic proximity Read ↗

Specific macrophage RhoA targeting CRISPR-Cas9 for mitigating osteoclastogenesis-induced joint damage in inflammatory arthritisSemantic proximity Read ↗

Plasma carboxypeptidase B downregulates inflammatory responses in autoimmune arthritis.Semantic proximity Read ↗

Dupuytren's contracture-associated SNPs increase SFRP4 expression in non-immune cells including fibroblasts to enhance inflammation development.Semantic proximity Read ↗

Receptor activator of nuclear factor kappa-B ligand (RANKL) but not sclerostin or gene polymorphisms is related to joint destruction in early rheumatoid arthritis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.