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Article

Structure and regulation of human epithelial cell transforming 2 protein.

Proceedings of the National Academy of Sciences of the United States of America - 14 Jan 2020

Chen Mengran, Pan Han, Sun Lingfei, Shi Peng, Zhang Yikan, Li Le, Huang Yuxing, Chen Jianhui, Jiang Peng, Fang Xianyang, Wu Congying, Chen Zhucheng

Abstract excerpt

Epithelial cell transforming 2 (Ect2) protein activates Rho GTPases and controls cytokinesis and many other cellular processes. Dysregulation of Ect2 is associated with various cancers. Here, we report the crystal structure of human Ect2 and complementary mechanistic analyses. The data show the C-terminal PH domain of Ect2 folds back and blocks the canonical RhoA-binding site at the catalytic center of the DH...

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Identifiers

PMID: 31888991
DOI: 10.1073/pnas.1913054117
PMCID: PMC6969500

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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