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Article

Deregulation and mislocalization of the cytokinesis regulator ECT2 activate the Rho signaling pathways leading to malignant transformation.

The Journal of biological chemistry - 20 Feb 2004

Saito Shin'ichi, Liu Xiu-Fen, Kamijo Keiju, Raziuddin Razi, Tatsumoto Takashi, Okamoto Isamu, Chen Xiaoyan, Lee Chong-Chou, Lorenzi Matthew V, Ohara Naoya, Miki Toru

Abstract excerpt

The human ECT2 protooncogene encodes a guanine nucleotide exchange factor for the Rho GTPases and regulates cytokinesis. Although the oncogenic form of ECT2 contains an N-terminal truncation, it is not clear how the structural abnormality of ECT2 causes malignant transformation. Here we show that...

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Source

Identifiers

PMID: 14645260
DOI: 10.1074/jbc.M306725200

Genes

ECT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-14645260-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Deregulation and mislocalization of the cytokinesis regulator ECT2 activate the Rho signaling pathways leading to malignant transformation.PMID 14645260Read ↗

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