Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Deregulation and mislocalization of the cytokinesis regulator ECT2 activate the Rho signaling pathways leading to malignant transformation.

The Journal of biological chemistry - 20 Feb 2004

Saito Shin'ichi, Liu Xiu-Fen, Kamijo Keiju, Raziuddin Razi, Tatsumoto Takashi, Okamoto Isamu, Chen Xiaoyan, Lee Chong-Chou, Lorenzi Matthew V, Ohara Naoya, Miki Toru

Abstract excerpt

The human ECT2 protooncogene encodes a guanine nucleotide exchange factor for the Rho GTPases and regulates cytokinesis. Although the oncogenic form of ECT2 contains an N-terminal truncation, it is not clear how the structural abnormality of ECT2 causes malignant transformation. Here we show that both the removal of the negative regulatory domain and alteration of subcellular localization are required to induce...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Catalytic Domain
Share to COS Cells

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cytoplasm

Share to Cytoskeleton

Share to Luciferases

Share to Microscopy, Video

Share to NIH 3T3 Cells

Share to rho GTP-Binding Proteins

Source

Identifiers

PMID: 14645260
DOI: 10.1074/jbc.M306725200

Genes

ECT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Deregulation and mislocalization of the cytokinesis regulator ECT2 activate the Rho signaling pathways leading to malignant transformation.PMID 14645260Read ↗

The tandem BRCT domains of Ect2 are required for both negative and positive regulation of Ect2 in cytokinesis.Semantic proximity Read ↗

The Ect2 Rho Guanine Nucleotide Exchange Factor Is Essential for Early Mouse Development and Normal Cell Cytokinesis and MigrationSemantic proximity Read ↗

Structure and regulation of human epithelial cell transforming 2 protein.Semantic proximity Read ↗

The Sec14 homology domain regulates the cellular distribution and transforming activity of the Rho-specific guanine nucleotide exchange factor Dbs.Semantic proximity Read ↗

Phosphorylation of the cytokinesis regulator ECT2 at G2/M phase stimulates association of the mitotic kinase Plk1 and accumulation of GTP-bound RhoA.Semantic proximity Read ↗

Distinct overlapping sequences at the carboxy-terminus of merlin regulate its tumour suppressor and morphogenic activity.Semantic proximity Read ↗

Identification of a novel RalGDS-related protein as a candidate effector for Ras and Rap1.Semantic proximity Read ↗

Elevated expression of Ets2 or distinct portions of Ets2 can reverse Ras-mediated cellular transformation.Semantic proximity Read ↗

Cdc42 in oncogenic transformation, invasion, and tumorigenesis.Semantic proximity Read ↗

Rit, a non-lipid-modified Ras-related protein, transforms NIH3T3 cells without activating the ERK, JNK, p38 MAPK or PI3K/Akt pathways.Semantic proximity Read ↗

Leukemia-associated RhoGEF (LARG) is a novel RhoGEF in cytokinesis and required for the proper completion of abscission.Semantic proximity Read ↗

Stimulation of hTAFII68 (NTD)-mediated transactivation by v-Src.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.