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Article

Modelling TERT regulation across 19 different cancer types based on the MIPRIP 2.0 gene regulatory network approach.

BMC bioinformatics - 30 Dec 2019

Poos Alexandra M, Kordaß Theresa, Kolte Amol, Ast Volker, Oswald Marcus, Rippe Karsten, König Rainer

Abstract excerpt

BACKGROUND: Reactivation of the telomerase reverse transcriptase gene TERT is a central feature for unlimited proliferation of the majority of cancers. However, the underlying regulatory processes are only partly understood. RESULTS: We assembled regulator binding information from serveral sources to construct a generic human and mouse gene regulatory network. Advancing our "Mixed Integer linear Programming based...

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Identifiers

PMID: 31888467
DOI: 10.1186/s12859-019-3323-2
PMCID: PMC6937852

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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