Identification and catalogue of viral transcriptional regulators in human diseases

Abstract excerpt

Viral genomes encode viral transcriptional regulators (vTRs) that manipulate host gene expression to facilitate replication and evade immune detection. Nevertheless, their role in non-cancerous diseases remains largely underexplored. Here, we unveiled 268 new candidate vTRs from 14 viral families. We mapped vTRs’ genome-wide binding profiles and identified their potential human targets, which were enriched in immu...

Topics

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• Single-cell and spatial transcriptomics
• CAR-T cell therapy research
• Cytomegalovirus and herpesvirus research
• Lymphoma Diagnosis and Treatment
• Polyomavirus and related diseases
• T-cell and B-cell Immunology
• T-cell and Retrovirus Studies
• Viral-associated cancers and disorders

Identifiers and source

Literature Corpus work

73095c0c-4104-5647-b06e-a95fbf708ddc

DOI

10.1101/2024.10.06.616669