Article
Germline Variants Incidentally Detected via Tumor-Only Genomic Profiling of Patients With Mesothelioma.
JAMA network open - 1 Aug 2023
Mitchell Owen D, Gilliam Katie, Del Gaudio Daniela, McNeely Kelsey E, Smith Shaili, Acevedo Maria, Gaduraju Meghana, Hodge Rachel, Ramsland Aubrianna S S, Segal Jeremy, Das Soma, Hathaway Feighanne, Bryan Darren S, Tawde Sanjukta, Galasinski Shelly, Wang Peng, Tjota Melissa Y, Husain Aliya N, Armato Samuel G, Donington Jessica, Ferguson Mark K, Turaga Kiran, Churpek Jane E, Kindler Hedy L, Drazer Michael W
Abstract excerpt
Importance: Patients with mesothelioma often have next-generation sequencing (NGS) of their tumor performed; tumor-only NGS may incidentally identify germline pathogenic or likely pathogenic (P/LP) variants despite not being designed for this purpose. It is unknown how frequently patients with mesothelioma have germline P/LP variants incidentally detected via tumor-only NGS. Objective: To determine the prevalence...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.