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Aβ reduction in BACE1 heterozygous null 5XFAD mice is associated with transgenic APP level

7 Jan 2015

Abstract excerpt

BACKGROUND: The β-secretase, BACE1, cleaves APP to initiate generation of the β-amyloid peptide, Aβ, that comprises amyloid plaques in Alzheimer's disease (AD). Reducing BACE1 activity is an attractive therapeutic approach to AD, but complete inhibition of BACE1 could have mechanism-based side-effects as BACE1-/- mice show deficits in axon guidance, myelination, memory, and other neurological processes. Since...

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PMID: 25567526
DOI: 10.1186/1750-1326-10-1

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