Article
Partial BACE1 reduction in a Down syndrome mouse model blocks Alzheimer-related endosomal anomalies and cholinergic neurodegeneration: role of APP-CTF.
Neurobiology of aging - 1 Mar 2016
Jiang Ying, Rigoglioso Andrew, Peterhoff Corrinne M, Pawlik Monika, Sato Yutaka, Bleiwas Cynthia, Stavrides Philip, Smiley John F, Ginsberg Stephen D, Mathews Paul M, Levy Efrat, Nixon Ralph A
Abstract excerpt
β-amyloid precursor protein (APP) and amyloid beta peptide (Aβ) are strongly implicated in Alzheimer's disease (AD) pathogenesis, although recent evidence has linked APP-βCTF generated by BACE1 (β-APP cleaving enzyme 1) to the development of endocytic abnormalities and cholinergic neurodegeneration in early AD. We show that partial BACE1 genetic reduction prevents these AD-related pathological features in the Ts2...
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