Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phosphorylation of amyloid precursor protein by mutant LRRK2 promotes AICD activity and neurotoxicity in Parkinson's disease.

Science signaling - 18 Jul 2017

Chen Zhong-Can, Zhang Wei, Chua Ling-Ling, Chai Chou, Li Rong, Lin Lin, Cao Zhen, Angeles Dario C, Stanton Lawrence W, Peng Jian-He, Zhou Zhi-Dong, Lim Kah-Leong, Zeng Li, Tan Eng-King

Abstract excerpt

Mutations in LRRK2, which encodes leucine-rich repeat kinase 2, are the most common genetic cause of familial and sporadic Parkinson's disease (PD), a degenerative disease of the central nervous system that causes impaired motor function and, in advanced stages, dementia. Dementia is a common symptom of another neurodegenerative disease, Alzheimer's disease, and research suggests that there may be...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyloid beta-Protein Precursor
Share to Dopamine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dopaminergic Neurons

Share to Leucine-Rich Repeat Serine-Threonine Protein Kinase-2

Share to Mice, Transgenic

Share to Parkinson Disease

Share to Phosphorylation

Share to Protein Interaction Domains and Motifs

Source

Identifiers

PMID: 28720718
DOI: 10.1126/scisignal.aam6790

Genes

APP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phosphorylation of amyloid precursor protein by mutant LRRK2 promotes AICD activity and neurotoxicity in Parkinson's disease.PMID 28720718Read ↗

The APP intracellular domain promotes LRRK2 expression to enable feed-forward neurodegenerative mechanisms in Parkinson's disease.Semantic proximity Read ↗

Mechanisms of LRRK2-dependent neurodegeneration: role of enzymatic activity and protein aggregation.Semantic proximity Read ↗

The AICD interactome: implications in neurodevelopment and neurodegenerationSemantic proximity Read ↗

Mutations in LRRK2 impair NF-κB pathway in iPSC-derived neurons.Semantic proximity Read ↗

Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration.Semantic proximity Read ↗

Regulation between LRRK2 and PP2A signaling in cellular models of Parkinson’s diseaseSemantic proximity Read ↗

Molecular biology changes associated with LRRK2 mutations in Parkinson's disease.Semantic proximity Read ↗

Phosphorylation of amyloid beta (Aβ) peptides - a trigger for formation of toxic aggregates in Alzheimer's disease.Semantic proximity Read ↗

Tau Protein Mediates APP Intracellular Domain (AICD)-Induced Alzheimer's-Like Pathological Features in Mice.Semantic proximity Read ↗

Small things matter: Implications of APP intracellular domain AICD nuclear signaling in the progression and pathogenesis of Alzheimer’s diseaseSemantic proximity Read ↗

LRRK2 I2020T mutation is associated with tau pathology.Semantic proximity Read ↗

alpha-synuclein and LRRK2: partners in crime.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.