Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Orai1, a Direct Target of microRNA-519, Promotes Progression of Colorectal Cancer via Akt/GSK3β Signaling Pathway.

Digestive diseases and sciences - 1 Jun 2016

Deng Wei, Wang Jin, Zhang Jun, Cai Jun, Bai Zhigang, Zhang Zhongtao

Abstract excerpt

BACKGROUND: Orai1, which is involved in store-operated calcium entry, has recently been implicated in cancer progression. However, the role of Orai1 in colorectal cancer (CRC) progression remains unclear. METHODS: We used real-time PCR and western blot to measure Orai1 expression in four CRC cell lines, 60 tumor pairs, and corresponding non-tumor tissues from CRC patients. Immunohistochemistry was performed to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line, Tumor
Share to Colorectal Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Glycogen Synthase Kinase 3 beta

Share to MicroRNAs

Share to ORAI1 Protein

Share to Proto-Oncogene Proteins c-akt

Share to Signal Transduction

Source

Identifiers

PMID: 26792278
DOI: 10.1007/s10620-015-4029-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Orai1, a Direct Target of microRNA-519, Promotes Progression of Colorectal Cancer via Akt/GSK3β Signaling Pathway.PMID 26792278Read ↗

MALAT1-related signaling pathways in colorectal cancerSemantic proximity Read ↗

Orai1-mediated store-operated Ca2+ entry promotes cervical cancer progression through IL-6 signalingSemantic proximity Read ↗

Association of Orai1 and Peizo1 genes expression with cellular proliferation, metastasis and angiogenesis biomarkers in colon tumor biopsies of CRC patients.Semantic proximity Read ↗

MDFI promotes the proliferation and tolerance to chemotherapy of colorectal cancer cells by binding ITGB4/LAMB3 to activate the AKT signaling pathwaySemantic proximity Read ↗

LncRNA BLACAT1/miR-519d-3p/CREB1 Axis Mediates Proliferation, Apoptosis, Migration, Invasion, and Drug-Resistance in Colorectal Cancer ProgressionSemantic proximity Read ↗

miR-1307–3p overexpression inhibits cell proliferation and promotes cell apoptosis by targeting ISM1 in colon cancerSemantic proximity Read ↗

Long non‐coding RNA RUNX1‐IT1 plays a tumour‐suppressive role in colorectal cancer by inhibiting cell proliferation and migrationSemantic proximity Read ↗

Molecular and cellular pathways in colorectal cancer: apoptosis, autophagy and inflammation as key playersSemantic proximity Read ↗

Long noncoding RNA EPB41L4A‐AS1 functions as an oncogene by regulating the Rho/ROCK pathway in colorectal cancerSemantic proximity Read ↗

Long non-coding RNA Malat1 activated autophagy, hence promoting cell proliferation and inhibiting apoptosis by sponging miR-101 in colorectal cancerSemantic proximity Read ↗

CLCA1 suppresses colorectal cancer aggressiveness via inhibition of the Wnt/beta-catenin signaling pathwaySemantic proximity Read ↗

Functional genetic screen identifies ITPR3/calcium/RELB axis as a driver of colorectal cancer metastatic liver colonizationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.