Article
Translocations involving c-myc and c-myc function.
Oncogene - 10 Sept 2001
Boxer L M, Dang C V
Abstract excerpt
c-MYC is the prototype for oncogene activation by chromosomal translocation. In contrast to the tightly regulated expression of c-myc in normal cells, c-myc is frequently deregulated in human cancers. Herein, aspects of c-myc gene activation and the function of the c-Myc protein are reviewed. The c-myc gene produces an oncogenic transcription factor that affects diverse cellular processes involved in cell growth,...
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