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Article

Structural insights into ubiquinone biosynthesis in membranes.

Science (New York, N.Y.) - 21 Feb 2014

Cheng Wei, Li Weikai

Abstract excerpt

Biosynthesis of ubiquinones requires the intramembrane UbiA enzyme, an archetypal member of a superfamily of prenyltransferases that generates lipophilic aromatic compounds. Mutations in eukaryotic superfamily members have been linked to cardiovascular degeneration and Parkinson's disease. To understand how quinones are produced within membranes, we report the crystal structures of an archaeal UbiA in its apo and...

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Identifiers

PMID: 24558159
DOI: 10.1126/science.1246774
PMCID: PMC4390396

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