Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional impact of cytochrome P450 3A (CYP3A) missense variants in cattle.

Scientific reports - 23 Dec 2019

Giantin Mery, Rahnasto-Rilla Minna, Tolosi Roberta, Lucatello Lorena, Pauletto Marianna, Guerra Giorgia, Pezzato Francesca, Lopparelli Rosa M, Merlanti Roberta, Carnier Paolo, Capolongo Francesca, Honkakoski Paavo, Dacasto Mauro

Abstract excerpt

Cytochrome P450 3A is the most important CYP subfamily in humans, and CYP3A4/CYP3A5 genetic variants contribute to inter-individual variability in drug metabolism. However, no information is available for bovine CYP3A (bCYP3A). Here we described bCYP3A missense single nucleotide variants (SNVs) and evaluated their functional effects. CYP3A28, CYP3A38 and CYP3A48 missense SNVs were identified in 300 bulls of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Catalytic Domain
Share to Cricetulus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP3A

Share to Microsomes, Liver

Share to Molecular Docking Simulation

Share to Multigene Family

Share to Nifedipine

Share to Testosterone

Source

Open in PubMed Open full text

Identifiers

PMID: 31873175
DOI: 10.1038/s41598-019-56271-8
PMCID: PMC6927969

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional impact of cytochrome P450 3A (CYP3A) missense variants in cattle.PMID 31873175Read ↗

Genetic findings and functional studies of human CYP3A5 single nucleotide polymorphisms in different ethnic groups.Semantic proximity Read ↗

Genetic variants of CYP3A4 and CYP3A5 in cynomolgus and rhesus macaques.Semantic proximity Read ↗

Pharmacogenomics of poor drug metabolism in greyhounds: Canine P450 oxidoreductase genetic variation, breed heterogeneity, and functional characterization.Semantic proximity Read ↗

Identification of variants of CYP3A4 and characterization of their abilities to metabolize testosterone and chlorpyrifos.Semantic proximity Read ↗

Functional characterization of five CYP2C8 variants and prediction of CYP2C8 genotype-dependent effects on in vitro and in vivo drug-drug interactions.Semantic proximity Read ↗

Genomic signatures of selection in drug metabolizing genes across cattle populations.Semantic proximity Read ↗

CYP2D44 polymorphisms in cynomolgus and rhesus macaques.Semantic proximity Read ↗

Conservation of glutathione S-transferase mRNA and protein sequences similar to human and horse Alpha class GST A3-3 across dog, goat, and opossum speciesSemantic proximity Read ↗

Development of genotyping method for functionally relevant variants of cytochromes P450 in cynomolgus macaques.Semantic proximity Read ↗

Genetic variants in dog cytochrome P450 2B6 and their relevance to interindividual variability of oxidations of probe drug propofol.Semantic proximity Read ↗

In Silico Analysis of PORD Mutations on the 3D Structure of P450 Oxidoreductase.Semantic proximity Read ↗

Flavin-Containing Monooxygenase 3 Polymorphic Variants Significantly Affect Clearance of Tamoxifen and Clomiphene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.