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Article

In Silico Analysis of PORD Mutations on the 3D Structure of P450 Oxidoreductase.

Molecules (Basel, Switzerland) - 21 Jul 2022

Nurhafizuddin Muhammad, Azizi Aziemah, Ming Long Chiau, Shafqat Naeem

Abstract excerpt

Cytochrome P450 oxidoreductase (POR) is a membrane-bound flavoprotein that helps in transferring electrons from its NADPH domain to all cytochrome P450 (CYP450) enzymes. Mutations in the POR gene could severely affect the metabolism of steroid hormones and the development of skeletal muscles, a condition known as Cytochrome P450 oxidoreductase deficiency (PORD). PORD is associated with clinical presentations of...

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PMID: 35889519
DOI: 10.3390/molecules27144646
PMCID: PMC9323898

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