Conservation of glutathione S-transferase mRNA and protein sequences similar to human and horse Alpha class GST A3-3 across dog, goat, and opossum species

Abstract excerpt

Recently, the glutathione S-transferase A3-3 (GST A3-3) homodimeric enzyme was identified as the most efficient enzyme that catalyzes isomerization of the precursors of testosterone, estradiol, and progesterone in the gonads of humans and horses. However, the presence of GST A3-3 orthologs with equally high ketosteroid isomerase activity has not been verified in other mammalian species, even though pig and cattle...

Topics

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• Amino Acid Substitution
• Binding Sites
• Crystallography, X-Ray
• Glutathione Transferase
• Kinetics
• Models, Molecular
• Mutation
• Substrate Specificity

Identifiers and source

Literature Corpus work

18ab986c-4a11-56aa-b663-6cdc9336e89b

DOI

10.1101/2020.11.25.396168