Article
Medulloblastoma Genotype Dictates Blood Brain Barrier Phenotype.
Cancer cell - 11 Apr 2016
Phoenix Timothy N, Patmore Deanna M, Boop Scott, Boulos Nidal, Jacus Megan O, Patel Yogesh T, Roussel Martine F, Finkelstein David, Goumnerova Liliana, Perreault Sebastien, Wadhwa Elizabeth, Cho Yoon-Jae, Stewart Clinton F, Gilbertson Richard J
Abstract excerpt
The childhood brain tumor, medulloblastoma, includes four subtypes with very different prognoses. Here, we show that paracrine signals driven by mutant β-catenin in WNT-medulloblastoma, an essentially curable form of the disease, induce an aberrant fenestrated vasculature that permits the accumulation of high levels of intra-tumoral chemotherapy and a robust therapeutic response. In contrast, SHH-medulloblastoma,...
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