Article
Genetic diversity and natural selection on the thrombospondin-related adhesive protein (TRAP) gene of Plasmodium falciparum on Bioko Island, Equatorial Guinea and global comparative analysis.
Malaria journal - 2 Mar 2021
Lin Li-Yun, Huang Hui-Ying, Liang Xue-Yan, Xie Dong-De, Chen Jiang-Tao, Wei Hua-Gui, Huang Wei-Yi, Ehapo Carlos Salas, Eyi Urbano Monsuy, Li Jian, Wang Jun-Li, Zheng Yu-Zhong, Zha Guang-Cai, Wang Yu-Ling, Chen Wei-Zhong, Liu Xiang-Zhi, Mo Huan-Tong, Chen Xin-Yao, Lin Min
Abstract excerpt
BACKGROUND: Thrombospondin-related adhesive protein (TRAP) is a transmembrane protein that plays a crucial role during the invasion of Plasmodium falciparum into liver cells. As a potential malaria vaccine candidate, the genetic diversity and natural selection of PfTRAP was assessed and the global PfTRAP polymorphism pattern was described. METHODS: 153 blood spot samples from Bioko malaria patients were collected...
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