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Article

Utilization of sequence variants as biomarkers to analyze population dynamics in cloned cell lines.

Biotechnology and bioengineering - 1 Aug 2017

Lin Tzihsuan Jennifer, Beal Kathryn M, DeGruttola Heather S, Brennan Steven, Marzilli Lisa A, Anderson Karin

Abstract excerpt

The inherent nature of cloned CHO cell lines includes the presence of genetic and phenotypic drift that leads to heterogeneous populations. The genetic heterogeneity exhibited by these cells can be exploited to understand the population dynamics of cloned cell lines. Understanding the interplay between heterogeneity, cell culture conditions, and population dynamics will allow for critical assessment of...

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PMID: 28369783
DOI: 10.1002/bit.26298

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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