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Article

Joint Location–Specific JAK ‐ STAT Signaling in Rheumatoid Arthritis Fibroblast‐like Synoviocytes

31 Oct 2019

Abstract excerpt

Objective Rheumatoid arthritis ( RA ) fibroblast‐like synoviocytes ( FLS ) derived from hip and knee have distinctive DNA methylation and transcriptome patterns in interleukin ( IL )‐6 signaling and Janus kinase ( JAK )–signal transducers and activators of transcription ( STAT ) pathways. To determine the functional effects of these joint‐specific signatures, we evaluated how RA hip and knee FLS differ in their...

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PMID: 31872186
DOI: 10.1002/acr2.11093

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