Article
Functional genomics atlas of synovial fibroblasts defining rheumatoid arthritis heritability.
Genome biology - 25 Aug 2021
Ge Xiangyu, Frank-Bertoncelj Mojca, Klein Kerstin, McGovern Amanda, Kuret Tadeja, Houtman Miranda, Burja Blaž, Micheroli Raphael, Shi Chenfu, Marks Miriam, Filer Andrew, Buckley Christopher D, Orozco Gisela, Distler Oliver, Morris Andrew P, Martin Paul, Eyre Stephen, Ospelt Caroline
Abstract excerpt
BACKGROUND: Genome-wide association studies have reported more than 100 risk loci for rheumatoid arthritis (RA). These loci are shown to be enriched in immune cell-specific enhancers, but the analysis so far has excluded stromal cells, such as synovial fibroblasts (FLS), despite their crucial involvement in the pathogenesis of RA. Here we integrate DNA architecture, 3D chromatin interactions, DNA accessibility,...
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