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Article

An imprinted rheumatoid arthritis methylome signature reflects pathogenic phenotype

30 Apr 2013

Abstract excerpt

BACKGROUND: A DNA methylation signature has been characterized that distinguishes rheumatoid arthritis (RA) fibroblast like synoviocytes (FLS) from osteoarthritis (OA) FLS. The presence of epigenetic changes in long-term cultured cells suggest that rheumatoid FLS imprinting might contribute to pathogenic behavior. To understand how differentially methylated genes (DMGs) might participate in the pathogenesis of...

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PMID: 23631487
DOI: 10.1186/gm444

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