Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A GWAS approach identifies Dapp1 as a determinant of air pollution-induced airway hyperreactivity.

PLoS genetics - 1 Dec 2019

Maazi Hadi, Hartiala Jaana A, Suzuki Yuzo, Crow Amanda L, Shafiei Jahani Pedram, Lam Jonathan, Patel Nisheel, Rigas Diamanda, Han Yi, Huang Pin, Eskin Eleazar, Lusis Aldons J, Gilliland Frank D, Akbari Omid, Allayee Hooman

Abstract excerpt

Asthma is a chronic inflammatory disease of the airways with contributions from genes, environmental exposures, and their interactions. While genome-wide association studies (GWAS) in humans have identified ~200 susceptibility loci, the genetic factors that modulate risk of asthma through gene-environment (GxE) interactions remain poorly understood. Using the Hybrid Mouse Diversity Panel (HMDP), we sought to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing
Share to Air Pollutants

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Asthma

Share to Bronchial Hyperreactivity

Share to Chromosome Mapping

Share to Disease Models, Animal

Share to Gene-Environment Interaction

Share to Lipoproteins

Source

Open in PubMed Open full text

Identifiers

PMID: 31869344
DOI: 10.1371/journal.pgen.1008528
PMCID: PMC6944376

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A GWAS approach identifies Dapp1 as a determinant of air pollution-induced airway hyperreactivity.PMID 31869344Read ↗

Integrative genetic analysis of allergic inflammation in the murine lung.Semantic proximity Read ↗

Inhalation of diesel exhaust and allergen alters human bronchial epithelium DNA methylationSemantic proximity Read ↗

Genetic interactions between chromosomes 11 and 18 contribute to airway hyperresponsiveness in mice.Semantic proximity Read ↗

Identification of novel chromosomal regions associated with airway hyperresponsiveness in recombinant congenic strains of mice.Semantic proximity Read ↗

Alterations of the lung methylome in allergic airway hyper‐responsivenessSemantic proximity Read ↗

Identification of PCDH1 as a novel susceptibility gene for bronchial hyperresponsiveness.Semantic proximity Read ↗

Genetic variability of T cell responses in hypersensitivity pneumonitis identified using the BXD genetic reference panel.Semantic proximity Read ↗

Genetic susceptibility to PM2.5 exposure and transcriptional responses in pediatric asthma: insights from single-cell transcriptomics.Semantic proximity Read ↗

Inhalation of allergen and diesel exhaust increases urinary eicosanoids associated with impaired lung function and airway hyperresponsiveness: a randomized, double-blinded, human crossover studySemantic proximity Read ↗

Diesel exhaust augments allergen-induced lower airway inflammation in allergic individuals: a controlled human exposure study.Semantic proximity Read ↗

Quantitative locus analysis of airway hyperresponsiveness in A/J and C57BL/6J mice.Semantic proximity Read ↗

Integration of mouse and human genome-wide association data identifies KCNIP4 as an asthma gene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.