Article

Inhalation of allergen and diesel exhaust increases urinary eicosanoids associated with impaired lung function and airway hyperresponsiveness: a randomized, double-blinded, human crossover study

2020-11-11

Abstract excerpt

<h4>Background: </h4> Eicosanoids are potent regulators of homeostasis and inflammation that play an important role in asthma pathophysiology. In a controlled human exposure study, we showed that coexposure to an allergen and diesel exhaust (DE) led to eosinophilic inflammation, impaired airflow, and increased airway responsiveness. Eicosanoids may mediate the mechanism by which these exposures impair lung functio...

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Literature Corpus work: 68dd2bdb-4557-544d-8301-c867726e2133
DOI: 10.22541/au.160510143.36483188/v1

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