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Article

Virtual mutagenesis of isocitrate dehydrogenase 1 involved in glioblastoma multiforme.

Chinese medical journal - 1 Sept 2011

Wang Ming-dong, Shi Yan-fang, Wang Hong, Wang Jia-liang, Ma Wen-bin, Wang Ren-zhi

Abstract excerpt

BACKGROUND: Site A132Arg mutations potentially impair the affinity of isocitrate dehydrogenase 1 (IDH1) for its substrate isocitrate (ICT), consequently reducing the production of α-ketoglutarate and leading to tumor growth through the induction of the hypoxia-inducible factor-1 (HIF-1) pathway. However, given that the roles of other active sites in IDH1 substrate binding remain unclear, we aimed to investigate...

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Source

Identifiers

PMID: 22040412

Genes

IDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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