Article
Molecular mechanisms of isocitrate dehydrogenase 1 (IDH1) mutations identified in tumors: The role of size and hydrophobicity at residue 132 on catalytic efficiency.
The Journal of biological chemistry - 12 May 2017
Avellaneda Matteo Diego, Grunseth Adam J, Gonzalez Eric R, Anselmo Stacy L, Kennedy Madison A, Moman Precious, Scott David A, Hoang An, Sohl Christal D
Abstract excerpt
Isocitrate dehydrogenase 1 (IDH1) catalyzes the reversible NADP+-dependent conversion of isocitrate (ICT) to α-ketoglutarate (αKG) in the cytosol and peroxisomes. Mutations in IDH1 have been implicated in >80% of lower grade gliomas and secondary glioblastomas and primarily affect residue 132, which helps coordinate substrate binding. However, other mutations found in the active site have also been identified in...
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