Article
Meta-GWAS Reveals Novel Genetic Variants Associated with Urinary Excretion of Uromodulin.
Journal of the American Society of Nephrology : JASN - 1 Mar 2022
Joseph Christina B, Mariniello Marta, Yoshifuji Ayumi, Schiano Guglielmo, Lake Jennifer, Marten Jonathan, Richmond Anne, Huffman Jennifer E, Campbell Archie, Harris Sarah E, Troyanov Stephan, Cocca Massimiliano, Robino Antonietta, Thériault Sébastien, Eckardt Kai-Uwe, Wuttke Matthias, Cheng Yurong, Corre Tanguy, Kolcic Ivana, Black Corrinda, Bruat Vanessa, Concas Maria Pina, Sala Cinzia, Aeschbacher Stefanie, Schaefer Franz, Bergmann Sven, Campbell Harry, Olden Matthias, Polasek Ozren, Porteous David J, Deary Ian J, Madore Francois, Awadalla Philip, Girotto Giorgia, Ulivi Sheila, Conen David, Wuehl Elke, Olinger Eric, Wilson James F, Bochud Murielle, Köttgen Anna, Hayward Caroline, Devuyst Olivier
Abstract excerpt
BACKGROUND: Uromodulin, the most abundant protein excreted in normal urine, plays major roles in kidney physiology and disease. The mechanisms regulating the urinary excretion of uromodulin remain essentially unknown. METHODS: We conducted a meta-analysis of genome-wide association studies for raw (uUMOD) and indexed to creatinine (uUCR) urinary levels of uromodulin in 29,315 individuals of European ancestry from...
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