Article
Rat P2X7 Receptor Show Functional Independence Between Macropore Formation and Scavenger Activity.
International journal of molecular sciences - 17 Feb 2026
Mena Javier, Leiva-Salcedo Elías, Araya-Dapremont Natalia, Bravo-Cabezas Francisco, Villa Ana Jane, Vivanco-Duarte Geraldine, Mejía Ángel, Galarce-Keidong Valentina, Lee Matías, Espinola-Gonzalez Francisca, Nuñez-Rojas Nelly, Varas Nayiberg, Schäfer Carolina, Mella-Torres Andrea, Huidobro-Toro Juan Pablo, Maisey Kevin, Bachelet Vivienne C, Escobar Alejandro, Barrera-Avalos Carlos, Acuña-Castillo Claudio
Abstract excerpt
The purinergic ionotropic receptor P2X7 stands out from other members of the P2X family due to its ability to form a macropore, activate multiple intracellular signaling pathways, and, as more recently reported, to mediate scavenger activity toward apoptotic cells. In addition, P2X7 exhibits a high number of single nucleotide polymorphisms (SNPs) and splice variants, several of which have been shown to impair...
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