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Article

PIP(2) regulates the ionic current of P2X receptors and P2X(7) receptor-mediated cell death.

Channels (Austin, Tex.) - 1 Jan 2000

Zhao Qi, Yang Min, Ting Adrian T, Logothetis Diomedes E

Abstract excerpt

P2X(7) receptors are non-selective cation channels gated by extracellular ATP. Prolonged stimulation of the P2X(7) receptor leads to an increase in cell permeability, cytokine release and apoptosis/necrosis. Application of PIP(2) to inside-out patches strongly activated all homomeric members of the P2X receptor family, including P2X(7) channels. Blockade of PIP(2) re-synthesis or induction of PIP(2) hydrolysis...

Read the complete abstract on PubMed

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Share to Adenosine Triphosphate
Share to Apoptosis
Share to Mice, Inbred BALB C

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Necrosis

Share to Phosphatidylinositol 4,5-Diphosphate

Share to Protein Structure, Tertiary

Share to Receptors, Purinergic P2

Share to Receptors, Purinergic P2X7

Source

Identifiers

PMID: 19151591

Genes

PIP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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