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Article

The Expression Levels of TREX1 and IFN-α Are Associated with Immune Reconstitution in HIV-1-Infected Individuals.

Viruses - 25 Mar 2024

Queiroz Maria Alice Freitas, Oliveira Allysson Quintino Tenório de, Moura Tuane Carolina Ferreira, Brito Wandrey Roberto Dos Santos, Santana Emmanuelle Giuliana Mendes, Lima Lorena Leticia Peixoto de, Lopes Felipe Teixeira, Bichara Carlos David Araújo, Amoras Ednelza da Silva Graça, Ishak Ricardo, Vallinoto Izaura Maria Vieira Cayres, Vallinoto Antonio Carlos Rosário

Abstract excerpt

TREX1 acts in the initial prevention of an autoimmune response, but it may contribute to the permissiveness of retrovirus infections. This study investigated the association between the levels of TREX1 gene expression with the polymorphisms TREX1 rs3135941 (T/C) and TREX1 rs3135945 (G/A), and the presence of antinuclear antibodies (ANA) in antiretroviral therapy (ART)-naïve individuals and after 1 year of...

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Share to Anti-Retroviral Agents
Share to Antibodies, Antinuclear
Share to CD4-Positive T-Lymphocytes
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Source

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Identifiers

PMID: 38675842
DOI: 10.3390/v16040499
PMCID: PMC11054413

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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