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Article

Rare variants in the TREX1 gene and susceptibility to autoimmune diseases.

BioMed research international - 1 Jan 2013

Barizzone Nadia, Monti Sara, Mellone Simona, Godi Michela, Marchini Maurizio, Scorza Raffaella, Danieli Maria G, D'Alfonso Sandra

Abstract excerpt

TREX1 (DNase III) is an exonuclease involved in response to oxidative stress and apoptosis. Heterozygous mutations in TREX1 were previously observed in patients with systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS). We performed a mutational analysis of the TREX1 gene on three autoimmune diseases: SLE (210 patients) and SS (58 patients), to confirm a TREX1 involvement in the Italian population, and...

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Open in PubMed Open full text

Identifiers

PMID: 24224166
DOI: 10.1155/2013/471703
PMCID: PMC3810194

Genes

TREX1

Variants

Provenance

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