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Association of TREX1 polymorphism with disease progression in human immunodeficiency virus type-1 (HIV-1) infected patients.

Virus genes - 1 Dec 2023

Tohidi Nastaran, Manshadi Seyed Ali Dehghan, Hajiabdolbaghi Mahboubeh

Abstract excerpt

The time interval between HIV-1 infection and AIDS development is not the same in all patients and depends largely on the genetic background of the individual. Polymorphisms in the TREX1 gene, the main enzyme in the clearance of cytosolic DNA, affect type 1 interferon-mediated inflammatory response in HIV-1 infection. We aimed to study the role of a single nucleotide polymorphism (rs3135941) of the TREX1 gene and...

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PMID: 37728706
DOI: 10.1007/s11262-023-02032-9

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