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Article

Evaluating the effect of multiple genetic risk score models on colorectal cancer risk prediction.

Gene - 5 Oct 2018

Xin Junyi, Chu Haiyan, Ben Shuai, Ge Yuqiu, Shao Wei, Zhao Yang, Wei Yongyue, Ma Gaoxiang, Li Shuwei, Gu Dongying, Zhang Zhengdong, Du Mulong, Wang Meilin

Abstract excerpt

Currently, genetic risk score (GRS) model has been a widely used method to evaluate the genetic effect of cancer risk prediction, but seldom studies investigated their discriminatory power, especially for colorectal cancer (CRC) risk prediction. In this study, we applied both simulation and real data to comprehensively compare the discriminability of different GRS models. The GRS models were fitted by logistic...

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PMID: 29908285
DOI: 10.1016/j.gene.2018.06.035

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