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Performance of common genetic variants in risk prediction for colorectal cancer in Chinese: A two-stage and multicenter study.

Genomics - 1 May 2021

He Cai-Yun, Chen Le-Zong, Wang Zi-Xian, Sun Li-Ping, Peng Jun-Jie, Wu Min-Qing, Wang Tong-Min, Li Ya-Qi, Yang Xin-Hua, Zhou Da-Lei, Ye Zu-Lu, Ma Jiang-Jun, Li Xi-Zhao, Zhang Pei-Fen, Ju Huai-Qiang, Mo Hai-Yu, Zhang Zi-Chen, Zeng Zhao-Lei, Shao Jian-Yong, Jia Wei-Hua, Cai San-Jun, Yuan Yuan, Xu Rui-Hua

Abstract excerpt

The efficacy of susceptible variants derived from genome-wide association studies (GWAs) optimizing discriminatory accuracy of colorectal cancer (CRC) in Chinese remains unclear. In the present validation study, we assessed 75 recently identified variants from GWAs. A risk predictive model combining 19 variants using the least absolute shrinkage and selection operator (LASSO) statistics offered certain clinical...

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PMID: 33545268
DOI: 10.1016/j.ygeno.2021.01.025

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