Article
C282Y-HFE gene variant affects cholesterol metabolism in human neuroblastoma cells.
PloS one - 1 Jan 2014
Ali-Rahmani Fatima, Huang Michael A, Schengrund C-L, Connor James R, Lee Sang Y
Abstract excerpt
Although disruptions in the maintenance of iron and cholesterol metabolism have been implicated in several cancers, the association between variants in the HFE gene that is associated with cellular iron uptake and cholesterol metabolism has not been studied. The C282Y-HFE variant is a risk factor for different cancers, is known to affect sphingolipid metabolism, and to result in increased cellular iron uptake....
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