Article
Sex differences in risk of lung cancer associated with methylene-tetrahydrofolate reductase polymorphisms.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jun 2005
Shi Qiuling, Zhang Zhendong, Li Guojun, Pillow Patricia C, Hernandez Ladia M, Spitz Margaret R, Wei Qingyi
Abstract excerpt
Methylenetetrahydrofolate reductase (MTHFR) catalyzes the metabolism of folate and nucleotides needed for DNA synthesis and repair. Variations in MTHFR functions likely play roles in the etiology of lung cancer. The MTHFR gene has three nonsynonymous single nucleotide polymorphisms (i.e., C677T, A1298C, and G1793A) that have a minor allele frequency of >5%. We investigated the associations between the frequencies...
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