Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Discovery and Selection of Hepatitis B Virus-Derived T Cell Epitopes for Global Immunotherapy Based on Viral Indispensability, Conservation, and HLA-Binding Strength.

Journal of virology - 17 Mar 2020

de Beijer Monique T A, Jansen Diahann T S L, Dou Yingying, van Esch Wim J E, Mok Juk Yee, Maas Mariëlle J P, Brasser Giso, de Man Robert A, Woltman Andrea M, Buschow Sonja I

Abstract excerpt

Immunotherapy represents an attractive option for the treatment of chronic hepatitis B virus (HBV) infection. The HBV proteins polymerase (Pol) and HBx are of special interest for antigen-specific immunotherapy because they are essential for viral replication and have been associated with viral control (Pol) or are still expressed upon viral DNA integration (HBx). Here, we scored all currently described HBx- and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD8-Positive T-Lymphocytes
Share to Epitopes, T-Lymphocyte

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Products, pol

Share to Hepatitis B, Chronic

Share to HLA-A2 Antigen

Share to HLA Antigens

Share to Immunotherapy

Share to Interferon-gamma

Source

Open in PubMed Open full text

Identifiers

PMID: 31852786
DOI: 10.1128/JVI.01663-19
PMCID: PMC7081907

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Discovery and Selection of Hepatitis B Virus-Derived T Cell Epitopes for Global Immunotherapy Based on Viral Indispensability, Conservation, and HLA-Binding Strength.PMID 31852786Read ↗

Rational Design of a Multiepitope Vaccine Encoding T-Lymphocyte Epitopes for Treatment of Chronic Hepatitis B Virus InfectionsSemantic proximity Read ↗

A systematic review of T-cell epitopes in hepatitis B virus: identification, genotypic variation and relevance to antiviral therapeutics.Semantic proximity Read ↗

A new unconventional HLA-A2-restricted epitope from HBV core protein elicits antiviral cytotoxic T lymphocytes.Semantic proximity Read ↗

Amino Acid Substitutions within HLA-B*27-Restricted T Cell Epitopes Prevent Recognition by Hepatitis Delta Virus-Specific CD8+ T Cells.Semantic proximity Read ↗

Proteogenomic identification of Hepatitis B virus (HBV) genotype-specific HLA-I restricted peptides from HBV-positive patient liver tissues.Semantic proximity Read ↗

Immunogenicity of twenty peptides representing epitopes of the hepatitis B core and surface antigens by IFN-γ response in chronic and resolved HBV.Semantic proximity Read ↗

Immune escape pathways from the HBV core18-27 CD8 T cell response are driven by individual HLA class I alleles.Semantic proximity Read ↗

Host ethnicity and virus genotype shape the hepatitis B virus-specific T-cell repertoire.Semantic proximity Read ↗

Identification of hepatitis B virus-specific CTL epitopes presented by HLA-A*2402, the most common HLA class I allele in East Asia.Semantic proximity Read ↗

In Silico Prediction of Human Leukocytes Antigen (HLA) Class II Binding Hepatitis B Virus (HBV) Peptides in Botswana.Semantic proximity Read ↗

Identification of HLA-A3 and -B7-restricted CTL response to hepatitis C virus in patients with acute and chronic hepatitis C.Semantic proximity Read ↗

CD8+ T-Cell Response-Associated Evolution of Hepatitis B Virus Core Protein and Disease Progress.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.